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We have developed a strategy to rewire the integrin-mediated adhesion of cells.83 For many cells, more than one integrin type mediates adhesion to the matrix, making it difficult to disentangle the roles of distinct receptors. We have developed a chimera approach wherein the extracellular domain of the integrin is replaced with a different protein receptor. We have shown that cells that are engineered with these chimeric receptors display many functions that are characteristic of integrin-mediated adhesion, including migration.
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